CABG surgery is associated with accelerated cognitive decline more than five years after the procedure in a long-lived population. This decline was restricted to individuals who were more than five years past the procedure and was not evident in the early years after the surgery. Study participants who had CABG surgery evidenced 0.95 points of greater decline relative to baseline on the 3MS at the first follow-up interview after CABG, and an average of 1.9 points of greater decline at the second follow-up interview, than those without CABG (t = -2.51, df = 2,316, p = 0.0121), after adjusting for several covariates, including number of vascular conditions. Multilevel models were used to examine the relationship between CABG surgery and cognitive decline over time. The main outcome measure was the Modified Mini Mental State (3MS). Individuals who reported having undergone CABG surgery at study baseline or had this surgery in between follow-up waves were compared to individuals who never reported having the surgery.
At baseline the study enrolled 5,092 persons age 65 and older and followed them up three years later and again four years after that.
This was a population-based cohort study involving participants in the Cache County Study of Memory Health and Aging. The relationship between coronary artery bypass graft ( CABG) surgery and cognitive decline remains uncertain, in particular with regard to whether there is delayed cognitive decline associated with this procedure. Lyketsos, Constantine G Toone, Leslie Tschanz, Joann Corcoran, Christopher Norton, Maria Zandi, Peter Munger, Ron Breitner, John C S Welsh-Bohmer, Kathleen
ZARAH JOY MANGAO POSTS 2012 TRIAL
This effectiveness trial will provide crucial information on the impact of a widely generalizable evidence-based collaborative care strategy for treating depressed patients with cardiac disease.Ī population-based study of the association between coronary artery bypass graft surgery ( CABG) and cognitive decline: the Cache County study. Secondary hypotheses will examine the impact of our intervention on mood symptoms, cardiovascular morbidity, employment, health services utilization, and treatment costs. Effect of exercise training program in post-CRET post-CABG patients with normal and subnormal ejection fraction (EF > 50% or 50% or 50% or 50% or or=10) and (2) 150 patients who served as nondepressed controls (PHQ-9 or=0.5 improvement in HRQoL at 8 months post CABG, as measured by the SF-36 Mental Component Summary score.
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